Hematoma (RR = 1.08 and RR = 0.87) showed no significant difference. Wound dehiscence (RR = 0.74 and RR = 1.15) and hospital readmission (RR = 0.90 and RR = 0.62) showed lower risks in NPWT group but were not significant. NPWT group showed significant decrease in the risk of SSI (RR = 0.45) and seroma (RR = 0.61) in observational studies with P value <0.05, as well as RCTs but were not significant (RR = 0.88 and RR = 0.68). Thirteen observational studies with 1923 patients and seven RCTs with 1091 patients were included. We performed a separate meta-analysis of observational studies and randomised controlled trials (RCTs) with CI 95%. The secondary outcome was hospital readmission. The first outcome was wound complications, divided into surgical site infection (SSI), seroma, hematoma, and wound dehiscence. This study aimed to review the risks and benefits of NPWT in surgical wounds with the underlying malignant disease compared with conventional wound care (CWC). N2 - The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis. International Wound Journal published by Inc (3M) and John Wiley & Sons Ltd. T2 - A meta-analysis of observational studies and randomised controlled trials T1 - Negative pressure wound therapy versus conventional wound care in cancer surgical wounds NPWT is not contraindicated in cancer surgical wounds and can be considered a beneficial palliative treatment to promote wound healing.", NPWT is not contraindicated in cancer surgical wounds and can be considered a beneficial palliative treatment to promote wound healing.Ībstract = "The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis. The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis.
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